Seit dem 11. September 1647 lebten bei dem Kardinal Mazarin von seiner jüngeren Schwester, Madame Mancini, zwei Töchter und ein Sohn und von seiner älteren Schwester, Madame Martinozzi, die älteste Tochter in Paris. "... the Cardinal was congratulated on their grace, and beauty. ... The elder of the girls, Laura Victoria Mancini, was thirteen years old - a bright sparkling brunette, with wonderfully expressive features, and an air of great sensibility. Her manners were timid, and her voice sweet and low. The second of the Cardinal's nieces was named Olympia: she was a girl of nine - awkward, tiny in stature, with large shining eyes, a dingy complexion, pointed chin, and magnificent black hair, which, according to the fashion of the time, enveloped her figure like a mantle. Shy and diffident, this little elf attracted much notice. Marie Anne Martinozzi, the daughter of the Cardinal's elder sister, was introduced as having more pretensions to the august sphere in which she suddenly found herself. She bore the title of La Contessa Mariana; and had been the betrothed bride of Don Carlo Barbarino, Prince of Palestrina, who, on the accession of Pope Innocent X., renounced his title, estates, and promised wife, for a cardinal's hat. Mademoiselle de Martinozzi was a lovely girl of twelve - fair, eyes blue as turquoise, her hair gold colour in hue, and so abundant ... The Cardinal's nephew, Giulio Mancini, was a pretty dark-haired boy of ten; but whose premature death caused all the great dignities in reserve for him, to fall to his younger brother Philip, who was born in the same year as Louis Quartze. ... Shortly after the arrival of these young ladies, Madame de Senécé, late governess of the King [Ludwig XIV.], accepted, with the brevet rank of a duchess, the office of governess to the three 'Mazarinettes', the name by which the Cardinal's nieces were soon nicknamed by the audacious Parisians." (in: Martha Walker Freer: The Regency of Anna of Austria -Queen Regent of France, Mother of Louis XIV, From numerous unpublished sources, including M88. in the Bibliothèque Impériale, and the Archives du Royaume de France, etc., etc., Vol. 1, London 1866, pp. 218-219). Übrigens besaß der Kardinal noch weitere hübsche Nichten: Maria Mancini (1639-1715), Hortense Mancini (1646-1699) und Maria Anna Mancini (1649-1714).
Die Wichtigkeit und Bedeutung von Mazarin für Anna von Spanien/Österreich zeigte sich besonders seit 1649. Seit dem Tod ihres Gatten im Jahr 1643 hatte sie schon jeden Abend mit ihm in politischen Gesprächen verbracht - bei offener Tür, damit keine bösen Gerüchte entstanden. Im Jahr 1649 sah es mittlerweile folgendermaßen aus: "The Cardinal [Mazarin] was now the Queen's constant companion, in the state cabinet, and closet. Anne always kept late hours, and far into the silent watches of the night their conferences extended. Mazarin soothed her distress ... He inspired into her mind prudent words and counselled gracious actions. The greatest master of diplomacy which the world then knew, Mazarin perfected the political education of Anne of Austria; and how well, and how aptly she profited by his instructions Anne showed when, a few months later, deprived of his support, alone, with every faction arrayed against her, she saved the crown by her dexterity, and shrewdness." (in: Martha Walker Freer: The Regency of Anna of Austria - Queen Regent of France, Mother of Louis XIV, From numerous unpublished sources, including M88. in the Bibliothèque Impériale, and the Archives du Royaume de France, etc., etc., Vol. 2, id., p. 93). Ein Brief von Mazarin an Anna von Spanien/Österreich im Mai 1651: "Mon Dieu! how thankful should I be if you could read my heart! Then, indeed, would you be convinced that never friendship equalled the friendship that I bear you! I will even go so far as to assert, that all delight and pleasure leaves me, when I employ my time in other pursuits than in dreaming of you! Neither can I express to you the hate I bear to all those foes who try drive me from your mind, and exhort you to forget me - and this hate rises in proportion to the affection which I bear you. I believe that your friendship is beyond shortcoming; and such as you tell me. Mine for you, however, appears to me finer, and truer; inasmuch as, every moment I reproach myself for not giving you signal proof of it; which raises in my mind strange desires, and bold measures to obtain sight of you. If my dread of compromising you did not restrain me, I would hazard a thousand lives to see you. I cannot answer much longer for myself, unless I speedily descry remedy; for such attachment as I bear you, scorns prudence. I may be wrong and unjust, and I ask pardon - nevertheless, I believe were I in your place I would devise means, and have made some path by which we could meet. Let me know, whether I shall ever see you again, and when. ..." (in: Martha Walker Freer: The Regency of Anna of Austria - Queen Regent of France, Mother of Louis XIV, From numerous unpublished sources, including M88. in the Bibliothèque Impériale, and the Archives du Royaume de France, etc., etc., Vol. 2, id., pp. 395-396).
Für Ludwig XIV. war der Kardinal Mazarin, der "Vater", den er nicht hatte und den er über alles liebte. Als der Kardinal Mazarin im März 1661 im Sterben lag, war Ludwig XIV. daher sehr niedergeschlagen: "... the grief he felt for the state in which he saw the cardinal, whom he greatly loved. It was his first attachment; childhood had set its seal on this affection. ... The king was afflicted by the death of his minister [Kardinal Mazarin], and wept much. ... The king, the queens, and the whole Court went into mourning for the cardinal; a thing which had never before been done; for kings wear mourning for none but sovereigns, or princes who have the honour to be related to them, and he was neither the one nor the other." (in: Memoirs of Madame de Motteville, Volume 3, id., pp. 230/236/240).