Louise Elisabeth d'Orléans (1709-1742) war das sechste Kind und die fünfte Tochter des Herzogs von Orléans, Philippe II. (1674-1723), und seiner Gattin Françoise Marie von Bourbon (1677-1749) und eine Enkeltochter der berühmten Liselotte von der Pfalz (1652-1722) und des französischen Königs Ludwig XIV. (1638-1715). Sie war zudem eine Cousine ersten Grades des Kaisers Franz Stephan von Lothringen (1708-1765), des Gatten der Kaiserin Maria Theresia. Geboren wurde sie am 11. Dezember 1709. Am 20. Januar 1722 wurde sie mit dem ersten Sohn des spanischen Königs Philipp V., Ludwig I. (1707-1724), verheiratet. Die Ehe währte wegen des frühen Todes ihres Gatten nur zwei Jahre und blieb kinderlos. Im März 1725, als man absolut sicher sein konnte, dass sie nicht schwanger war, wurde sie von ihrem Schwiegervater Philipp V. nach Frankreich zurückgeschickt, wo sie am 16. Juni 1742 in Paris verstarb.
Ihre Großmutter, Liselotte von der Pfalz, die Herzogin von Orléans, schrieb im Jahr 1717 über sie: "[Louise Elisabeth] ist ein gutt kindt, aber gar heßlich undt unahngenehm." Im November 1720 lesen wir dann in einem ihrer Briefe an die Königin von Preußen über jene: "Es ist erstaunlich, wie spanisch sie aussieht: sie ist sehr ernst, lacht praktisch nie und spricht sehr wenig. Sie ist brünett, und ihre Augen sind fast schwarz. Vor ein paar Tagen hat sie mich besucht; sie trug ein Hauskleid nach spanischer Art; das steht ihr besser als die französischen Gewänder."
Liselotte von der Pfalz schrieb am 6. Dezember 1721 über ihre Enkelin Louise Elisabeth: "One cannot say that she is ugly; she has pretty eyes, a smooth, white skin, a well-shaped nose, though rather small, and a very tiny mouth. With all this she is the most disagreeable person that I have ever seen. In all her manners, whether she be talking, or eating, or drinking, she annoys one. So I did not shed any tears when we said good-bye, no more did she." (in: Edward Armstrong: Elisabeth Farnese – "The Termagant of Spain", id., p. 168).
Louise Elisabeth d'Orléans war in Spanien ebenfalls nicht beliebt. Durch ihren berühmten Zeitgenossen Saint-Simon wissen wir: "She [Louise Elisabeth] had always despised her husband, and disliked his step-mother [Elisabetta Farnese]. ... The blame is not to be attributed to Elisabeth [Elisabetta Farnese]. She had affectionately welcomed the young bride, had nursed her through an attack of erysipelas, had given her gruel with her own hands, and arranged her bed. These attentions had from the first met with unmannerly return. The girl refused to attend the State ball given in her honour; she hated dancing, for she danced incredibly badly, and it kept her up; whereas, unlike the queen, her maxim was early to bed and early to rise. She did not care for plays, and refused to hunt, for she detested shooting. Her only amusement consisted in childish jokes which she practised at table and upon the queen. S. Simon [Saint-Simon] was the witness and victim of the incredible vulgarity of her manners. Since her marriage she had sulked; she now gave the rein to her naturally high spirits ... Tired of rambling through the palace, she would take walks in the rain with her petticoats up to her knees, and not return till night-fall. Philip [V., ihr Schwiegervater] himself was horrified to see her running round the gardens at S. Ildefonso with no clothing but a dressing-gown with which the curious wind took liberties. She ate enormously, and at all hours, and would force her ladies to do likewise, waiting upon them herself, and slapping them if they refused to eat. To her husband she would never speak, and it was believed that he had always refused to consummate the marriage. She publicly insulted the Court of S. Ildefonso by refusing to allow Elisabeth's friend, the Duchess of S. Pierre, to kiss her hand. The young king at length inflicted a summary chastisement. Her coach was stopped on its return from one of her wild excursions, she was not allowed to return to the palace, and was placed in confinement. No attention was paid to her paroxysms of passion and shame. The old Marshal de Tessé took the opportunity to lecture her on her behaviour, and to prescribe a reconciliation. Her husband met her on her release, kissed her affectionately, and took her into his own carriage. The incident had produced a revulsion in her favour; the Spaniards thought the punishment too severe and too public for her offence, and attributed it to the vindictive nature of Elisabeth Farnese." (in: Edward Armstrong: Elisabeth Farnese – "The Termagant of Spain", id., pp. 164-165).