Grand Duke Ferdinand I. de' Medici of Tuscany (1549-1609)

Christina of Lorraine (1565-1636)

1. Federico Ubaldo della Rovere (1605-1623), son of Duke Francesco Maria II. della Rovere (1549-1631) of Urbino; marriage on 29. April 1621
2. Leopold V. (1586-1632), Archduke of Austria-Tyrol and former Bishop of Passau and Strasbourg; marriage on 19. April 1626

from her first marriage to Federico Ubaldo della Rovere (1605-1623):

1. her daughter Vittoria della Rovere, born on 7. February 1622, deceased on 5. March 1694

from her second marriage to Archduke Leopold V. (1586-1632):

1. her daughter Maria Eleonora, born on 9. February 1627, deceased on 29. July 1629 (of dysentery)
2. her son Ferdinand Karl, born on 17. May 1628, deceased on 30. December 1662
3. her daughter Isabella Klara, born on 12. August 1629, deceased on 24. February 1685; on 7. November 1649 she became married to Duke Charles II. Gonzaga of Mantua and Montferrat (1629-1665); a son, Ferdinand Charles I. Gonzaga (1652-1708), Duke of Mantua und Montferrat, resulted from this marriage
4. her son Sigismund Franz, Bishop of Augsburg (1646-1662), born on 28. November 1630, deceased on 25. June 1665; his wedding to Maria Hedwig Augusta of Sulzbach (1650-1681), daughter of Count Palatine Christian August of Sulzbach, was celebrated per procurationem on 3. June 1665; but he never saw his bride because of his death on 25. June 1665; he died of a stroke at the age of 35 or according to another historical source of high fever
5. her daughter Maria Leopoldine, born on 6. April 1632, deceased on 7. August 1649 as a consequence of the very difficult birth of her only child, her son Karl Josef (1649-1664); in 1648 she had been married to her cousin Emperor Ferdinand III. (1608-1657)