Francesco I. de' Medici († 1587), Grand Duke of Tuscany

Johanna or Giovanna of Austria († 1578), youngest daughter of Emperor Ferdinand I. († 1564)

Henry IV. (1553-1610), King of France; wedding per procurationem in Florence on 5. October 1600 and in persona in Lyon on 27. December 1600

1. her son Louis XIII., King of France, born on 27. September 1601, deceased on 14. May 1643; since 25. November 1615 married to Anna, the eldest daugther of King Philip III. of Spain († 1621); two children – very unhappy marriage
2. her daughter Elizabeth, Queen of Spain, born on 20. December 1602 (or, according to a different source, on 22. November 1603), deceased on 6. October 1644, married to King Philip IV. of Spain († 1665); eight children, only two of whom survived childhood
3. her daughter Christine, Duchess of Savoy, born on 10. February 1606, deceased on 27. December 1663, married to Duke Victor Amadeus I. of Savoy († 1637)
4. her son Henry, born on 16. April 1607, deceased on 17. November 1611
5. her son Gaston, Duke of Orléans, born on 25. April 1608, deceased on 2. February 1660; his first wife was Marie de Bourbon-Montpensier (1605-1627), his second wife was his great love Marguerite of Lorraine (1615-1672); Gaston had one daughter by his first wife: Anne Marie Louise (1627-1693), who went down in history as "La Grande Mademoiselle", and four daughters and one son by his second wife: Marguerite Louise (1645-1721), Grand Duchess of Tuscany; Elizabeth Marguerite (1646-1696), Duchess of Lorraine; Francoise Madeleine (1648-1664), Duchess of Savoy; his son Jean Gaston (1650-1652) and Marie Anne (1652-1656)
6. her daughter Henriette Maria, Queen of England, born on 26. November 1609, deceased on 10. September 1669, married to King Charles I. of England († 1649); nine children, only four of whom reached adulthood

• Maike Vogt-Luerssen: Maria de' Medici (in German only)