- 12. May 1590
- 28. February 1621 (of pulmonary consumption)
Grand Duke Ferdinand I. de' Medici of Tuscany (1549-1609)
Christina of Lorraine (1565-1636)
Maria Magdalena (1587-1631), daughter of Archduke Karl II. of Inner-Austria; in 1599 Cosimo's father, Ferdinand I. de Medici, asked in the name of his son for the hand of Maria Magdalena's elder sister Maria Christina, but the latter did not want to marry again after her very unhappy first marriage.