Fadrique Alvarez de Toledo, second Duke of Alba

Isabel de Zuñiga, Countess of Sarmiento; marriage in the year 1480

1. Maria Pimentel y Osorio (1498-1530), second Marchioness of Villafranca del Bierzo
2. Vincenza Spinelli

from his first marriage to Maria Pimentel y Osorio:

1. his son Federico, deceased in 1554 or 1555
2. his son Garzia, born in 1514, deceased in 1577; in 1552 he married Vittoria Colonna, daughter of Ascanio I. Colonna and Giovanna of Aragon; Garzia and Vittoria had the following six children: Eleonora (1553-1576), Pietro († 1627), Maria, Giovanna († 1593), Ines and Anna († 1596)
3. his daughter Isabella, deceased after 1551; in 1540 she was married to Giovanni Battista II. Spinelli, Duke of Castrovillari
4. his daughter Eleonora, born in 1522, deceased on 18. December 1562
5. his son Luigi; he married Violante de Moscoso Osorio y Alvarez de Toledo
6. his daughter Giovanna; she was married to Fernando Ximenez de Urrea
7. his daughter Anna; her first husband was Alvaro de Mendoza and her second husband was Alvaro Lope de Moscoso Osorio