Karoline Wilhelmine wurde am 2. September 1705 mit Georg August von Hannover, dem zukünftigen König Georg II. von Großbritannien, verheiratet, dem sie folgende Kinder schenkte: 1. ihren Sohn Friedrich Ludwig (1707-1751), seit 1716 Herzog von Gloucester und seit 1728 Prince of Wales; 2. ihre Tochter Anna (oder Anne) (1709-1759), seit 1734 mit dem zukünftigen Wilhelm IV. von Oranien, Statthalter der Vereinigten Provinzen der Niederlande, verheiratet; 3. ihre Tochter Amalia (oder Amelia) (1711-1786), die unverheiratet blieb; 4. ihre Tochter Caroline Elizabeth (1713-1759), ihr Lieblingskind, die ebenfalls unverheiratet blieb; die Totgeburt eines Sohnes am 20. November 1716; 5. ihren Sohn Georg Wilhelm (1717-1718); eine Fehlgeburt im Jahr 1718; 6. ihren Sohn Wilhelm August (1721-1765), Herzog von Cumberland; 7. ihre Tochter Maria (1723-1772), seit 1740 mit dem Landgrafen Friedrich II. von Hessen-Kassel verheiratet; und 8. ihre Tochter Louise (1724-1751), seit 1743 mit dem König Friedrich V. von Dänemark und Norwegen verheiratet; und eine Fehlgeburt im Juli 1725.
"That the Queen [Karoline Wilhelmine], whilst affecting to be led by the will of her husband, really ruled him, and that Walpole [the Premier Sir Robert Walpole] ruled the nation through the Queen, now became evident to every one save the King himself, who, poor silly mortal as he must have been, so little dreamed that his clever consort seriously interfered with public matters, or influenced him by her counsel, that to those about him he perpetually repeated, 'she never meddles with business;' and to show how independent he believed himself to be, he 'one day,' says Lord Hervey, 'remarked, Charles I. was governed by his wife, Charles II. by his mistress, King James by his priests, King William by his men, Queen Anne by her favourite woman, his father by anybody who could get to him;' and then, with an air of triumph, he exclaimed, 'and who do they say governs now?' The courtiers present replied, as all good courtiers would have done, with a compliment; but shortly afterwards, a wit, with more rudeness, but greater truth wrote - 'You may strut, dapper George, but 'twill all be in vain, You know 'tis Queen Caroline, not you, that reign; You govern no more than Don Philip of Spain, Then if you would have us fall down and adore you, Lock up your fat spouse, as your dad did before you.'" (in: Francis Lancelott: The Queens of England and Their Times: Matilda, Queen of William the Conqueror, to Adelaide, Queen of William the Fourth, Volume 2, id., p. 923).
"Again, on the fifth of June, 1735, the King [George II.] set out on a visit to Hanover, and whilst he was there, basking in the deceptive sunshine of pleasure and illicit love, the Queen [Karoline Wilhelmine], as Regent, in conjunction with Sir Robert Walpole, the premier, ruled the nation with laudable ability and success. Caroline viewed her husband's departure with pleasure, for it freed her during his absence from the trouble of ruling through him, and from the annoyance of his almost unbearable petulancy. But her pride was wounded by intelligence which he forwarded to her shortly after his arrival, and from which she learned that he had found a new mistress in Madame Walmoden [Amalie Sophie Marianne von Wallmoden-Gimbon (1704-1765), geborene von Wendt], a young married German lady, who deserted her husband for the King, and, after the Queen's death, was created Countess of Yarmouth. Lord Hervey, after asserting that the pride of the Queen was much more hurt than her affections on this occasion, proceeds - 'It is certain, too that from the very beginning of this new engagement, the King acquainted the Queen, by letter, of every step he took in it, of the growth of his passion, the progress of his applications, and their success - of every word as well as every action that passed; so minute a description of her person, that had the Queen been a painter, she might have drawn her rival's picture at six hundred miles' distance; he added, too, the account of his buying her, and what he gave her, which, considering the rank of the purchaser, and the merits of the purchase, as he set them forth, I think he had no great reason to brag of, when the first price, according to his report, was only 1000 ducats, a much greater proof of his economy than his passion.'" (in: Francis Lancelott: The Queens of England and Their Times: Matilda, Queen of William the Conqueror, to Adelaide, Queen of William the Fourth, Volume 2, id., pp. 928-929).