15. December 1485

7. January 1536

Ferdinand II. (1452-1516), King of Aragón and Naples-Sicily

Isabella the Catholic (1451-1504), Queen of Castile and León

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• her sister Isabella, born on 1. October 1470, deceased after the birth of her only child, her son Miguel, from puerperal fever on 25. August 1498; since 1490 in her first marriage married to the Portuguese heir apparent to the throne Alfonso († 1491 – riding accident), the son of João II., King of Portugal, and of Leonor of Aragón; no children; in her second marriage married to Manuel I. († 1521), King of Portugal, a cousin of João II.; one son, Miguel, born on 23. August 1498, deceased on 20. July 1500
• her brother Juan, born on 30. June 1478, deceased on 4. October 1497, married to Margaret of Austria († 1530), the daughter of Emperor Maximilian I. († 1519); no children
• her sister Juana or Johanna, born on 6. November 1479, deceased on 12. April 1555, married to Philipp the Fair († 1506), the son of Emperor Maximilian I. († 1519); six children
• her sister Mary, born on 29. June 1482, deceased on 7. March 1517, since 13. October 1500 married to her brother-in-law Manuel I. († 1521), King of Portugal; they had 10 Children: Johann III. (1502-1557), King of Portugal from 1521 until 1557, Isabella (1503-1539), wife of Emperor Charles V., and six more sons and two daughters

1. Arthur (1486-1502), the eldest son of Henry VII. of England († 1509) and his wife, Elizabeth of York († 1503); marriage on 14. November 1501 – no children
2. Henry VIII. of England (1491-1547), the second son of Henry VII. of England and his wife, Elizabeth of York; marriage on 11. May 1509 – after several miscarriages and stillbirths only one daughter remained, Mary Tudor (1516-1558)

Mary Tudor (1516-1558), Queen of England from 1553 until 1558