15. April 1452

2. May 1519

Ser Piero da Vinci (1424-1504)

Caterina or Chateria, probably a slave, with whom Leonardo's father had a short love affair; she married Achattabriga di Piero del Vaccha in 1457

from the third marriage of his father to Marguerita di Francesco di Jacopo di Guglielmo (1458 - c. 1486):

1. his half-brother Antonio, born in 1476
2. his half-sister Maddalena, born and deceased in 1477
3. his half-brother Giuliano, born in 1479
4. his half-brother Lorenzo, born in 1484
5. his half-sister Violanta, born in 1485
6. his half-brother Domenico, born in 1486

from the fourth marriage of his father to Lucrezia di Guglielmo Cortigiani (1464-after 1520):

7. his half-sister Margherita, born in 1491
8. his half-brother Benedetto, born in 1492
9. his half-brother Pandolfo, born in 1494
10. his half-brother Guglielmo, born in 1496
11. his half-brother Bartolomeo, born in 1497
12. his half-brother Giovanni, born in 1498

Isabella of Aragon (1470-1524), Duchess of Milan (clandestine marriage around 1495/96)

two sons and three daughters: Francesco, born around 1496/97, Giovanna, born in 1502, Maria, born in 1503, Antonio, born in 1506, and Isabella, born around 1509; his eldest daughter Giovanna of Aragon (1502-1575) was a well known celebrity in her time