26. April 1575

3. July 1642

Francesco I. de' Medici († 1587), Grand Duke of Tuscany

Johanna of Austria († 1578), youngest daughter of Emperor Ferdinand I. († 1564) (the family-tree of the dynasty of the Hapsburgs is available only in German)

Henry IV. (1553-1610), King of France; wedding per procurationem in Florence on 5. October 1600 and in persona in Lyon on 27. December 1600 (the family-tree of the dynasty of the Bourbons is available only in German)

1. her son Louis XIII., King of France, born on 27. September 1601, deceased on 14. May 1643; since 25. November 1615 married to Anna, the eldest daugther of King Philip III. of Spain († 1621); two children – very unhappy marriage (the family-tree of the dynasty of the Hapsburgs and Bourbons is available only in German)
2. her daughter Elizabeth, Queen of Spain, born on 20. December 1602 (or, according to a different source, on 22. November 1603), deceased on 6. October 1644, married to King Philip IV. of Spain († 1665); eight children, only two of whom survived childhood (the family-tree of the dynasty of the Hapsburgs and Bourbons is available only in German)
3. her daughter Christine, Duchess of Savoy, born on 10. February 1606, deceased on 27. December 1663, married to Duke Victor Amadeus I. of Savoy († 1637) (the family-tree of the dynasty of the Bourbons is available only in German)
4. her son Henry, born on 16. April 1607, deceased on 17. November 1611
5. her son Gaston, Duke of Orléans, born on 25. April 1608, deceased on 2. February 1660, first marriage to Marie de Bourbon-Montpensier († 1627), second marriage to Marguerite of Lorraine
6. her daughter Henriette Maria, Queen of England, born on 26. November 1609, deceased on 10. September 1669, married to King Charles I. of England († 1649); nine children, only four of whom reached adulthood (the family-tree of the dynasty of the Stuarts is available only in German)