4. August 1470

10./15. November 1553

Lorenzo „il Magnifico“ de' Medici (1449-1492)

Clarice Orsini (1453-1488), daughter of Jacopo Orsini of Monterotondo

Jacopo Salviati (1461-1533); marriage on 10. September 1486

1. her son Giovanni, born on 24. March 1490 or on 24. March 1491, deceased on 28. January 1553; Cardinal since 1517
2. her son Lorenzo, born on 8. July 1492, deceased on 16. July 1539; he married Costanza Conti, a member of one of the most prestigious families of the Roman nobility, in 1514
3. her son Piero, Knight of the Order of St. John, married to Caterina, daughter of Roberto Pallavicini
4. her daughter Elena († 1552); in her first marriage she was married to Margrave Pallavicino Pallavicini and in her second marriage since 1525 to Prince Jacopo V. d'Appiano d'Aragona
5. her son Battista, born in the year 1498, deceased in the year 1524; he married Costanza de' Bardi
6. her daughter Maria, born on 17. July 1499, deceased on 29. December 1543; she was married to the Great Condottiere Giovanni de' Medici (1498-1526) on 16. November 1516; Maria and Giovanni had one son, Cosimo (1519-1574)
7. her daughter Aloisia, she was married to Count Sigismondo of Caltabellotta
8. her daughter Francesca, born in 1505, in her first marriage she was married to Piero Gualterotti, with whom she had one daughter Maria, and in her second marriage to Ottaviano de' Medici (1484-1546), of whom she was the second wife; with her second husband she had one son, Alessandro Ottaviano de' Medici (1535-1605), the future Pope Leo XI.; Ottaviano de' Medici belonged to another branch of the Medici family tree; his great-great-great-grandfather Giovenco († 1320) was the younger brother of the great-grandfather of Cosimo the Elder de' Medici (1389-1464), whose name was Chiarissimo
9. her son Bernardo, born in the year 1508, deceased on 6. May 1568; Knight of the Order of St. John
10. her son Alamanno, born in the year 1510, deceased in the year 1571; he married Costanza Serristori