1. January 1449

8. April 1492

Piero "il Gottoso" de' Medici (1416-1469)

Lucrezia (1425/27-1482), daughter of Francesco di Simone Tornabuoni and Nanna di Niccolò di Luigi Guicciardini

Clarice Orsini (1453-1488), daughter of Jacopo Orsini of Monterotondo and of Maddalena of Bracciano; marriage per procurationem in December 1468, the real wedding was celebrated on 4. June 1469 in Florence; a very happy marriage: Lorenzo [de' Medici ] told Pope Innocent VIII shortly after Clarice's death [on 30 July 1488] that she was his 'most dear and beloved wife', and that it was so grievous to him, 'having been deprived of such a sweet manner and company', that he could find no peace. (in: B. Felice: Donne Medicee avanti il Principato, III: Clarice Orsini, moglie del Magnifico Lorenzo", pp. 53-73, in: Rassegna Nazionale 149, 1906, pp. 71-72)

1. his daughter Lucrezia, born on 4. August 1470, deceased on 10. or 15. November 1553

2. and 3. child: twins (two boys), premature birth in March 1471, the children lived just long enough to be baptized

4. his son Piero II., born on 15. February 1472, deceased on 28. December 1503

5. his daughter Maddalena, born on 25. July 1473, deceased on 2. December 1528

6. his daughter Contessina Beatrice, born on 23. September 1474, deceased in September 1474 or in 1475

7. his son Giovanni, the future Pope Leo X., born on 11. December 1475, deceased on 1. December 1521, Cardinal since March 1489

8. his daughter Luigia, born on 25. January 1477, deceased in July 1488

9. his daughter Contessina, born on 16. January 1478, deceased on 29. June 1515

10. his son Giuliano, Duke of Nemours, born on 12. March 1479, deceased on 17. March 1516; since 1515 married to Philiberta (1498-1524), a daughter of Duke Philip II. of Savoy; Giuliano had one illegitimate child by his mistress Pacifica Brandano, his son Ippolito (1511-1535)