
Francesco II. Maria Sforza, Herzog von Mailand von 1521-1524, 1525, 1529-1535; Cousin von Isabella von Aragon, mit dem Symbol der "Sforzanase"; mit 35 Jahren war er bereits ein schwer kranker Mann, wie der folgende Bericht (vom 11. Oktober 1530) des Venezianers Marino Sanudo zeigt: „... The duke [Francesco II. Maria Sforza] had difficulty walking -, and his ambassador, who lives here [in Venedig], went along with him, giving him a hand to help him. His Excellency was followed by his [half-]brother [Gian Paolo] ... The duke usually travels on a small mule... [he is] very melancholic; he has difficulty using his hands and walks poorly." (in: Venice – Cítà Excelentissima – Selections from the Renaissance Diaries of Marin Sanudo. Edited by Patricia H. Labalme and Laura Sanguineti White. Translated by Linda L. Carroll. Baltimore 2008, S. 78-79).
4. Februar 1495
31. Oktober/1. November 1535
Lodovico Maria il Moro Sforza († 1508), Herzog von Mailand
Beatrice d'Este († 1497), Tochter des Herzogs Ercole I. von Ferrara, Reggio und Modena († 1505)
Christina von Dänemark (1521-1590), Nichte des Kaisers Karl V. († 1558); Heirat am 28. September 1533 (per procurationem)
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